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1例46岁女性,因银屑病关节炎自行服用苦丹丸2丸(6 g),3次/d。用药5 d后出现乏力、腹胀,继续服药症状加重,19d后停药。停药第2天患者皮肤、巩膜明显黄染,收入院。血生化检查:丙氨酸转氨酶1384 U/L,天冬氨酸转氨酶1311 U/L,总胆红素91.4μmol/L,直接胆红素53.5μmol/L,间接胆红素37.9μmol/L。诊断为药物性肝损害,给予甘草酸二铵、还原型谷胱甘肽等治疗。20 d后患者症状消失,肝功能基本恢复正常,遂出院。
A 46-year-old female patient received 2 pills of Ku Dan pill (6 g) 3 times daily for psoriatic arthritis. 5 days after treatment, fatigue, abdominal distension, continue to medication symptoms aggravated, after 19d withdrawal. On the second day after stopping the patient’s skin, sclera significantly yellow dye, income hospital. Blood biochemical tests: alanine aminotransferase 1384 U / L, aspartate aminotransferase 1311 U / L, total bilirubin 91.4μmol / L, direct bilirubin 53.5μmol / L, indirect bilirubin 37.9μmol / L. Diagnosis of drug-induced liver damage, given diammonium glycyrrhizinate, glutathione reduction and other treatment. Symptoms disappeared after 20 days, liver function returned to normal, then discharged.