手性色谱法是体内药物分析的重要方法之一,其主要原因一是手性是生物体系的一个基本特征,很多内源性大分子物质,如酶、血浆、蛋白、多糖等具有手性特征,二是手性药物在药物中占有很大的比例,据报道,天然或半合成药物几乎都具有手性特征,全合成药物的40%为手性药物[1]。手性药物 Chiral chromatography is one of the important methods for in vivo drug analysis. One of the main reasons is that chirality is a basic feature of biological systems. Many endogenous macromolecules, such as enzymes, plasma, proteins and polysaccharides, have chiral characteristics Second, chiral drugs occupy a large proportion of the drugs. Almost all natural or semi-synthetic drugs have chiral characteristics, and 40% of all synthetic drugs are chiral drugs [1]. Chiral drugs