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目的探讨早期液体复苏在急性重症胰腺炎患者治疗中的应用效果,分析早期液体复苏的临床价值。方法将2014年1月—2016年1月治疗的55例重症胰腺炎患者随机分为实验组30例和对照组25例,对照组给予一般补液治疗,实验组给予早期液体复苏治疗,比较两组脏器功能损伤情况、液体潴留、肺水肿以及炎性介质清除率,数据进行统计学处理,P<0.05为差异有统计学意义。结果实验组呼吸衰竭发生率(13.3%)、肾功能不全发生率(6.7%)、病死率(3.3%)均低于对照组(24.0%、32.0%、16.0%),两组比较差异均有统计学意义(均P<0.05),实验组液体潴留(3.3%)、肺水肿发生率(6.7%)低于对照组(28.0%、32.0%),比较差异均有统计学意义(均P<0.05),其炎性介质清除率(90.0%)高于对照组(40.0%),比较差异有统计学意义(P<0.05)。结论早期液体复苏在急性重症胰腺炎治疗中可有效改善患者的脏器功能损伤,消除水肿减少渗出,提高炎性介质清除率,具有一定的临床价值。
Objective To investigate the effect of early liquid resuscitation in the treatment of patients with acute severe pancreatitis and to analyze the clinical value of early liquid resuscitation. Methods 55 cases of severe acute pancreatitis treated from January 2014 to January 2016 were randomly divided into experimental group (30 cases) and control group (25 cases). The control group received general rehydration therapy and the experimental group received early liquid resuscitation. Two groups Organ damage, fluid retention, pulmonary edema and inflammatory clearance rate, the data were statistically processed, P <0.05 for the difference was statistically significant. Results The incidence of respiratory failure (13.3%), renal insufficiency (6.7%) and mortality (3.3%) in the experimental group were significantly lower than those in the control group (24.0%, 32.0%, 16.0% (P <0.05). The fluid retention (3.3%) and the incidence of pulmonary edema in the experimental group (6.7%) were lower than those in the control group (28.0% and 32.0%, P < 0.05). The clearance rate of inflammatory mediators (90.0%) was higher than that of the control group (40.0%), the difference was statistically significant (P <0.05). Conclusion Early liquid resuscitation in the treatment of acute severe pancreatitis can effectively improve the patient’s organ damage, eliminate edema and reduce exudation and increase the clearance rate of inflammatory mediators, which has a certain clinical value.