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目的探讨不同绝经状态下中国女性BMI与乳腺癌发病的关系。方法计算机检索Pub Med、EMBASE、万方数据库、维普数据库、中国期刊全文数据库(CNKI),收集国内外2000年1月至2017年2月公开发表的关于中国女性不同体质指数(BMI)分组与乳腺癌发病关系的研究文献。应用Stata12.0进行Meta分析,在总体效应关系存在的基础上,进行线性和非线性模型拟合,若未发现剂量反应关系,再进一步探讨不同BMI对乳腺癌发病的截断效应,采用Begg’s检验评估发表偏倚。结果共纳入8篇文献,共103 141人。绝经前组合并后的效应量RR值为1.10(95%CI:0.95~1.27),绝经后组合并后的效应量RR值为1.52(95%CI:1.31~1.75),绝经前、后均未发现剂量-反应关系(X~2=1.95,PLinearity=0.16;=2.02,PNonlinearity=0.57)。相对于参照组(18.5 kg/m~228 kg/m~2)为1.83(95%CI:1.46~2.29)。Begg’s检验的Z=0.82,P=0.41,所纳入分析的文献不存在发表偏倚。结论在中国,BMI升高可增加绝经后女性乳腺癌的发病风险,而在绝经前女性人群中尚未发现此关联。
Objective To investigate the relationship between Chinese women’s BMI and breast cancer in different postmenopausal states. Methods PubMed, EMBASE, Wanfang database, VIP database and CNKI were searched by computer. The data of Chinese BMI group and breast from January 2000 to February 2017 were collected. Study of the relationship between cancer and cancer. Stata12.0 was used to carry out Meta-analysis. Based on the existence of the overall effect, linear and nonlinear models were fitted. If no dose-response relationship was found, the truncation effect of different BMIs on breast cancer was further investigated by Begg’s test Post bias. Results A total of 8 articles were included, a total of 103 141 people. The pre-menopausal combined RR RR was 1.10 (95% CI: 0.95-1.27) and the post-menopausal combined RR was 1.52 (95% CI: 1.31-1.75) before and after menopause Dose-response relationships were found (X ~ 2 = 1.95, PLinearity = 0.16; = 2.02, PNonlinearity = 0.57). Compared with the reference group (18.5 kg / m ~ 2 28 kg / m ~ 2). Z = 0.82 for Begg’s test, P = 0.41, and there was no publication bias in the included analyzes. Conclusions In China, elevated BMI increases the risk of breast cancer in postmenopausal women, a finding that has not been found in premenopausal women.