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用EIA和PCR方法对HCV感染孕妇的17名婴儿和3名引产胎儿进行了HCV母婴垂直传播研究。对17名婴儿随访1~2年。17名婴儿出生时IgG抗-HCV全部阳性,16名在半年内消失,仅1名HCVRNA持续阳性者生后12个月IgG抗-HCV仍然阳性。HCVRNA阳性孕妇的12名婴儿中2名检出HCVRNA,3例引产胎儿中1例检出HCVRNA。结果表明存在HCV母婴垂直传播,传播率为15%。
17 males and 3 aborted fetuses of HCV-infected pregnant women were tested for vertical transmission of maternal and females by EIA and PCR. 17 infants were followed up for 1 to 2 years. Seventeen infants with IgG anti-HCV were all positive at birth, 16 disappeared within six months, and only one HCVRNA persistently positive at 12 months after birth and IgG anti-HCV was still positive. Two out of 12 infants of HCVRNA-positive pregnant women detected HCVRNA and one out of 3 fetus fetuses detected HCVRNA. The results showed the presence of HCV mother and child vertical transmission, the transmission rate was 15%.