近年来,随着对下丘脑激素,尤其是对下丘脑-垂体-性腺轴激素分泌及其生理效应有调控作用的促黄体释放激素(LRH)的深入研究,已发现其有可能成为比较理想的男性避孕药,并引起了普遍关注。已发现:无论是 LRH 的激动性类似物或拮抗性类似物,还是 LRH 的免疫制剂,均可能干扰雄性激素的合成和精子的生成,从而达到抗生育的目的。当前对这一领域的研究十分活跃,本文择要予以介绍。 In recent years, with the further study of hypothalamic hormones, especially the luteinizing hormone releasing hormone (LRH), which regulates the secretion of the hypothalamus-pituitary-gonadotropin and its physiological effects, it has been found that it may be ideal Male contraceptives, and caused widespread concern. It has been found that both LRH agonistic analogs or antagonistic analogs and LRH immunosuppressive agents may interfere with androgen synthesis and sperm production to achieve anti-fertility. The current research on this field is very active, this article should be introduced.