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由皮癣菌引起的甲癣是一种常见病,念珠菌属及短帚毒亦可侵犯甲板。Goodfield 等报道用一种新的丙烯胺药terbinafine 治疗甲癣,其真菌治愈的时间约为临床时间的1/2(治疗趾甲癣约为24～44周),故较早即可清除真菌;而用其他治疗时真菌及临床治愈可同时发生。这些结果表明terbinafine 对甲板的穿透性比目前公认的快得多。且对20例作1年随访,各例真菌检查仍阴性,这是其他治疗所不能达到的。在体外低浓度的ter-binafine 可杀灭真菌,这就可以解释为何其可杀灭真菌而不是抑制其生长。即使治疗时间超过6个月亦无副作用。包括terbinafine 在内的丙烯胺抗真菌药物可通过阻止角鲨烯转变为角鲨烯环氧化物而抑制真菌细胞膜形成,terbinafine 杀灭真菌的机理尚不清楚,但早期的报道表明,该药亦可治愈其
Onychomycosis caused by onychomycosis is a common disease, Candida and short broom poison can also violate the deck. Goodfield et al. Reported that the treatment of onychomycosis with terbinafine, a new allylamine drug, took about 1/2 of the clinical time to cure the fungus (about 24-44 weeks of treatment of nails) so it cleared the fungus earlier; Fungal and clinical cure with other treatments can occur simultaneously. These results show that terbinafine penetrates the deck much faster than currently recognized. And 20 cases for 1 year follow-up, each case of fungal examination is still negative, which is not achieved by other treatments. Low concentrations of ter-binafine kill fungi in vitro, which explains why they kill fungi rather than inhibit their growth. Even if the treatment time of more than 6 months without side effects. Acrylamide antifungal drugs, including terbinafine, inhibit fungal cell membrane formation by inhibiting the conversion of squalene to squalene epoxide. The mechanism by which terbinafine kills fungi is unclear, although earlier reports indicated that the drug may also Heal it