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目的了解甘肃省朝觐人群血尿酸水平及高尿酸血症患病情况,并研究其相关因素,为防治高尿酸血症提供科学依据。方法对2010年7月赴麦加朝觐的1995例朝觐体检者的血尿酸及身高、体重、血压、空腹血糖、丙氨酸转氨酶、天氡氨酸转氨酶、尿素氮、肌酐水平进行统计分析。结果该朝觐人群血尿酸水平及高尿酸血症检出率为:回族男性(354.00±78.80)μmol/L和19.25%,女性(284.91±72.31)μmol/L和14.88%;东乡族男性(365.39±88.02)μmol/L和26.72%,女性(285.64±86.39)μmol/L和15.17%。回族、东乡族男性血尿酸水平及高尿酸血症患病率均明显高于女性,差异均有统计学意义(P<0.05)。东乡族男性高尿酸血症患病率明显高于回族男性,差异有统计学意义(χ2=6.564,P<0.05),女性间差异无统计学意义(P>0.05)。二项分类的非条件logistic回归分析结果显示,民族(OR=1.37,95%CI:1.03～1.82)、体质指数(OR=2.76,95%CI:1.99～3.82)、血压(OR=1.35,95%CI:1.05～1.73)、丙氨酸转氨酶(OR=1.57,95%CI:1.17～2.10)、尿素氮(OR=1.70,95%CI:1.31～2.20)、肌酐(OR=11.26,95%CI:3.00～42.20)均与高尿酸血症相关。结论甘肃省朝觐穆斯林人群高尿酸血症患病率较高,且民族、体质指数、血压及肝肾功能均与该人群的高尿酸血症患病率相关。
Objective To understand the prevalence of blood uric acid and hyperuricemia among pilgrims in Gansu Province and to study the related factors so as to provide a scientific basis for preventing and treating hyperuricemia. Methods Serum uric acid, body weight, blood pressure, fasting blood glucose, alanine aminotransferase, aspartate aminotransferase, urea nitrogen and creatinine in 1995 pilgrimage to Hajj in July 2010 were analyzed statistically. Results The detection rates of serum uric acid and hyperuricemia in the pilgrims were: Hui nationality men (354.00 ± 78.80) μmol / L and 19.25%, women (284.91 ± 72.31) μmol / L and 14.88%; Dongxiang nationality men (365.39 ± 88.02) μmol / L and 26.72%, and women (285.64 ± 86.39) μmol / L and 15.17% respectively. The prevalence of serum uric acid and hyperuricemia in Hui and Dongxiang ethnic groups were significantly higher than those in female group (P <0.05). The prevalence of hyperuricemia in male in Dongxiang nationality was significantly higher than that in Hui nationality male (χ2 = 6.564, P <0.05). There was no significant difference between female and male (P> 0.05). The results of non-conditional logistic regression analysis of the two categories showed that there were significant differences between the national (OR = 1.37, 95% CI: 1.03-1.82), body mass index (OR = 2.76, 95% CI: 1.99-3.82) (OR = 1.57, 95% CI: 1.17-2.10), urea nitrogen (OR = 1.70, 95% CI: 1.31-2.20) and creatinine (OR = 11.26,95% CI: 1.05-1.73) CI: 3.00 to 42.20) are associated with hyperuricemia. Conclusion The prevalence of hyperuricemia in Hajj Muslims in Gansu province is high, and the nationality, body mass index, blood pressure and liver and kidney function are related to the prevalence of hyperuricemia in this population.