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目的：探讨肝素的平喘作用。方法：采用豚鼠整体动物引喘法和兔改良肺溢流法观察肝素的平喘作用；采用Ｇｒｅｅｎ法观察肝素对豚鼠血清一氧化氮（ＮＯ）含量的影响；采用二甲苯诱发小鼠耳肿胀法以及大鼠松节油气囊肉芽肿法观察肝素对炎症的影响；采用小鼠断尾法和豚鼠玻管法观察肝素对出凝血时间的影响。结果：肝素气雾给药，５２０．８３、１０４１．６６Ｕ·ｋｇ－１可使豚鼠引喘潜伏期延长；５２０．８３Ｕ·ｋｇ－１可使兔肺溢流量减少；１０４１．６６Ｕ·ｋｇ－１可使豚鼠血清ＮＯ含量增加。但等剂量的肝素对动物的急、慢性炎症及出凝血时间无明显影响。结论：小剂量肝素气雾给药有明显的气道扩张及平喘作用；此剂量肝素的应用可避免出血倾向等不良反应的发生；其平喘１９９７－０１－３１收稿，１９９７－０３－０２修回作者简介：明亮，女，４９岁，副教授作用可能与抗炎作用无直接关系；ＮＯ含量升高与其平喘作用有何联系，尚待研究。
Objective: To investigate the antiasthmatic effect of heparin. Methods: The anti-asthmatic effect of heparin was observed by using guinea pig whole body asthmatic method and modified lung overflow method. The effect of heparin on serum nitric oxide (NO) content in guinea pigs was observed by Green method. And rat turpentine balloon granuloma was observed heparin on the impact of inflammation; the use of the mouse tail method and guinea pig glass tube method to observe the effect of heparin on the clotting time. Results: Heparin aerosol, 520.83,1041.66U · kg-1 guinea pigs can lead to prolonged latency to asthma; 520.83U · kg-1 can reduce the rabbit lung overflow; 1041.66U · kg-1 The guinea pig serum NO levels increased. However, the same dose of heparin on animal acute and chronic inflammation and clotting time had no significant effect. Conclusion: The administration of low-dose heparin aerosol has obvious airway expansion and antiasthmatic effect; the application of this dose of heparin to avoid the occurrence of bleeding and other adverse reactions; its asthma 1997-01-31 Received 1997-03-31, 02 Revised Author: Bright, female, 49 years old, associate professor may have no direct relationship with the role of anti-inflammatory; NO content with its role in the role of antiasthmatic, yet to be studied.