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肌病(Myopathy)是某些药物特别是皮质类甾醇和抗疟药治疗时的并发症。作者在本文首次报道一例使用利福平引起的严重近侧性肌病。患急性肺结核的44岁妇女,曾接受三个月的链霉素注射和16个月的异烟肼、利福平治疗。6年后症状复发,肺部出现新鲜空洞,采用链霉素、利福平、异烟肼和乙胺丁醇治疗四周,再复诊时主诉臂、腿近侧端肌无力,靠旁人帮助才能站立。停止全部的药物治疗后,24小时内肌无力好转,第8天肌力完全恢复。再给异烟肼治疗无不良反应。又给利福平治疗,在24小时内再次发生严重的肌无力。虽然肌电图检查正常,但肌肉活组织检
Myopathy is a complication of the treatment of certain drugs, especially corticosteroids and antimalarials. The authors report for the first time in this article a case of severe proximal myopathy caused by rifampicin. A 44-year-old woman with acute tuberculosis who had received streptomycin injections for 3 months and isoniazid and rifampin for 16 months had been treated. 6 years after the recurrence of symptoms, the lungs appear fresh and empty, the use of streptomycin, rifampicin, isoniazid and ethambutol treatment for four weeks, and then referral when the main complaint arm, leg proximal muscle weakness, by the help of others to stand . Stop all the drug treatment, muscle weakness improved within 24 hours, the first 8 days full recovery of muscle strength. Give isoniazid treatment without adverse reactions. Give rifampin treatment again in 24 hours again severe muscle weakness. Although EMG examination is normal, but muscle biopsy