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目的 :研究益寿调脂片抗衰老的临床疗效。方法 :6 0例符合纳入标准者随机分为治疗组和对照组 ,每组 30例。治疗组服益寿调脂片 ,对照组服绞股蓝总甙片 ,观察两组治疗前后血脂和脂蛋白含量、氧自由基、免疫功能、内分泌功能、血液流变学及微循环的变化。结果 :益寿调脂片能明显降低胆固醇、甘油三酯、动脉粥样硬化指数、载脂蛋白B、总羟脯氨酸、钙离子浓度和升高高密度脂蛋白胆固醇、载脂蛋白A水平 ;能明显提高血清超氧化物歧化酶 (SOD )活性和降低血清丙二醛 (MDA)含量 ;能显著增加免疫球蛋白、补体含量和提高T淋巴细胞亚群的水平 ;能明显升高睾酮水平和降低雌二醇、卵泡刺激素、黄体生成激素的水平 ;能显著降粘、降纤、改善红细胞变形性、抑制血小板聚集和改善微循环。治疗前后比较差异均有显著性 (P <0 .0 5 )。结论 :益寿调脂片具有抗衰老的作用。
Objective: To study the anti-aging clinical efficacy of Yishou Tiaozhi Tablet. Methods: Sixty patients who met the inclusion criteria were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group took Yishou Tiaozhi Tablets and the control group took Gynostemma scrophulari. The blood lipid and lipoprotein levels, oxygen free radicals, immune function, endocrine function, hemorheology and microcirculation changes were observed before and after treatment in the two groups. Results: Yishou Tiaozhi Tablet can significantly reduce cholesterol, triglyceride, atherosclerosis index, apolipoprotein B, total hydroxyproline, calcium ion concentration and increase high-density lipoprotein cholesterol, apolipoprotein A levels Can significantly increase serum superoxide dismutase (SOD) activity and reduce serum malondialdehyde (MDA) content; can significantly increase the level of immunoglobulin, complement and increase the level of T lymphocyte subsets; can significantly increase testosterone levels And reduce estradiol, follicle stimulating hormone, luteinizing hormone levels; can significantly reduce viscosity, reduce fiber, improve red blood cell deformability, inhibit platelet aggregation and improve microcirculation. Before and after treatment, the differences were significant (P < 0.05). Conclusion: Yishou Tiaozhi Tablet has anti-aging effect.