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目的:观察补肾化痰行气方联合二甲双胍治疗肥胖型多囊卵巢综合征(PCOS)伴胰岛素抵抗(IR)的临床疗效。方法:将80例肥胖型PCOS伴CIR患者随机分为观察组和对照组,每组40例,观察组给予补肾化痰行气方联合二甲双胍治疗;对照组采用二甲双胍治疗,3个月后比较两组患者治疗前后疗效,同时对体质量指数(BMI)、血清促黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)、胰岛素抵抗指数(HOMA-IR)进行比较分析。结果:观察组有效率为72.50%,对照组为52.50%,两组相比差异具有统计学意义(P<0.05);两组患者治疗前后及治疗后BMI、血清LH、LH/FSH、T、FINS、TG、HOMA-IR相比差异具有统计学意义(P<0.05);两组治疗后,血清TC均较治疗前差异具有统计学意义(P<0.05)。结论:补肾化痰行气方联合二甲双胍治疗肥胖型PCOS伴IR较单纯运用二甲双胍疗效更显著。
Objective: To observe the clinical efficacy of Bushen Huatan Qi combined with metformin in the treatment of obese patients with polycystic ovary syndrome (PCOS) and insulin resistance (IR). Methods: Eighty obese patients with PCOS and cirrhosis were randomly divided into observation group and control group, 40 cases in each group. The observation group was given Bushen Huatan Qi combined with metformin. The control group was treated with metformin. After 3 months, The curative effect was evaluated before and after treatment. The body mass index, serum LH, FSH, FIN, FIN, Glycerol (TG), insulin resistance index (HOMA-IR) were compared. Results: The effective rate was 72.50% in the observation group and 52.50% in the control group, with significant difference between the two groups (P <0.05). The BMI, serum LH, LH / FSH, T, FINS, TG and HOMA-IR were statistically significant (P <0.05). After treatment, serum TC levels were significantly different from those before treatment (P <0.05). Conclusion: Bushen Huatan Qi combined with metformin in treatment of obese patients with PCOS with IR is more effective than the simple use of metformin.