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目的:研究汞暴露秀丽线虫表型和行为缺陷在后代中的可传递特性。方法:寿命、身体尺寸、身体弯曲频率、头部摆动频率和化学趋向可塑性用于汞急性毒害评价,并进一步分析表型和行为缺陷从汞暴露的当代到后代的可传递特性。结果:汞暴露能够引起包括寿命、身体尺寸、身体弯曲频率、头部摆动频率和化学趋向可塑性等参数在内的多重生物学缺陷,且其毒害与所暴露汞浓度之间密切相关。大部分毒害能够从暴露线虫当代传递给后代。汞暴露对线虫后代寿命的毒害不能够明显恢复。汞暴露线虫后代身体尺寸的缺陷甚至比当代更为严重。此外,高浓度汞暴露通常导致非常纤细的线虫动物出现,且在后代中可观察到更多具有这种表型的线虫。汞暴露导致的线虫身体弯曲和头部摆动频率缺陷在后代中可以大部分或者完全恢复。尽管化学趋向可塑性在汞暴露线虫后代中能够部分恢复,但是化学趋向可塑性仍受到严重的破坏。结论:汞暴露引起的多重生物学毒害可以从暴露当代传递给它们的后代,并且在后代中出现的一些缺陷甚至比当代更为严重。
OBJECTIVE: To study the transmissibility characteristics of Mercury exposed C. elegans phenotypes and behavioral defects in offspring. METHODS: Lifetime, body size, body bending frequency, head swing frequency and chemotaxis plasticity were used to assess the acute toxicity of mercury and to further analyze the transmissibility of phenotypic and behavioral defects from the present to future generations of mercury exposure. Results: Exposure to mercury can cause multiple biological defects including parameters such as longevity, body size, body bending frequency, head swing frequency and chemical tendency plasticity, and its toxicity is closely related to the exposed mercury concentration. Most of the poison can be passed from the exposed nematode to the offspring. The toxicity of mercury exposure to the life of nematode can not be significantly restored. The defects in the body size of mercury-exposed nematode offspring are even more severe than in the contemporary era. In addition, exposure to high concentrations of mercury usually results in the appearance of very slender nematode animals, and more nematodes with this phenotype can be observed in offspring. Necrosis of the nematodes caused by mercury exposure and the frequency of head swing can be mostly or completely recovered in offspring. Although chemo-plasticity can partially recover in mercury-exposed nematode offspring, chemical tendencies to plasticity are still severely impaired. Conclusion: Multiple biological toxicities caused by mercury exposure can be passed on from their contemporary exposure to their descendants, and some of the shortcomings that occur in future generations are even more severe than in the present age.