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药物蛋白质组学是蛋白质组学技术在药物发现和药物开发过程中的应用。基于质谱的药物蛋白质组学是蛋白质组学的一个分支,在药物研发过程中起了越来越重要的作用。本文就近年来基于质谱的药物蛋白质组学在药物作用机制、药物潜在靶点的筛选及疾病的耐药性机制等研究中取得的进展进行综述。
Pharmacoproteomics is the application of proteomics in drug discovery and drug development. MS-Based Pharmacoproteomics is a branch of proteomics and plays an increasingly important role in the drug discovery process. This review summarizes recent advances in mass spectrometry-based proteomics of pharmacogenomics in the mechanisms of drug action, screening of potential drug targets and mechanisms of disease resistance.