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目的探讨丹参川芎嗪注射液治疗对慢性阻塞性肺疾病(COPD)患者肺功能及免疫功能的影响。方法将92例COPD患者采用随机数字表法分为观察组和对照组,每组46例,对照组患者给予祛痰、平喘、控制感染等对症治疗,观察组患者在此基础上应用丹参川芎嗪注射液治疗。比较两组患者治疗前后肺功能及免疫功能的变化。结果两组患者治疗后FEV1、FEV1/FVC均较治疗前明显升高,观察组升高程度明显优于对照组(P<0.01);观察组治疗后CD4+及CD4+/CD8+较治疗前及对照组治疗后均明显上升(P<0.01);对照组治疗前后免疫功能指标比较,差异无统计学意义(P>0.05)。结论丹参川芎嗪注射液辅助治疗COPD可有效改善患者的肺功能及免疫功能。
Objective To investigate the effects of ligustrazine injection on pulmonary function and immune function in patients with chronic obstructive pulmonary disease (COPD). Methods 92 cases of COPD patients were divided into observation group and control group using random number table method, 46 cases in each group. Patients in control group were given symptomatic treatment such as expectorant, antiasthmatic and infection control. Patients in observation group were given Salviae Miltiorrhizae Triazine injection treatment. The changes of pulmonary function and immune function in two groups before and after treatment were compared. Results After treatment, FEV1 and FEV1 / FVC in both groups were significantly higher than those before treatment (P <0.01), and the levels of CD4 + and CD4 + / CD8 in the observation group were significantly higher than those in the control group The levels of immune function in the control group before and after treatment showed no significant difference (P> 0.05). Conclusion Salviae miltiorrhizae ligustrazine injection adjuvant treatment of COPD can effectively improve the patient’s lung function and immune function.