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应用硫代巴比妥酸(TBA)法对46例格林-巴利综合征(GBS)患者与13例正常对照组共59份脑脊液进行了唾液酸(SA)的测定。结果显示:GBS患者脑脊液内SA含量(15.7±9μg/L)明显高于13例正常对照钮(平均6.2±4μg/L);重型GBS患者高于轻型患者,随着时间的推移,病情的好转,脑脊液内SA含量逐渐下降。提示脑脊液内SA含量能够反应出周围神经的损伤程度。
Fifty-nine CSF samples from 46 patients with GBS and 13 normal controls were assayed for sialic acid (SA) using thiobarbituric acid (TBA). The results showed that the content of SA in cerebrospinal fluid of patients with GBS (15.7 ± 9μg / L) was significantly higher than that of 13 normal controls (average 6.2 ± 4μg / L); patients with severe GBS were more severe than those with mild type of GBS. With the passage of time, , SA content in cerebrospinal fluid gradually decreased. Tip SA content in cerebrospinal fluid can reflect the degree of peripheral nerve injury.