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目的探讨慢性心力衰竭(CHF)患者治疗前后血清超敏C-反应蛋白(hs-CRP)和尿酸测定的临床价值。方法 105例CHF患者按NYHA分级标准分为Ⅱ～Ⅳ级,分别在治疗前后采血进行血清hs-CRP和尿酸水平测定,并与31例健康体检者(对照组)的水平进行比较。结果 CHF患者治疗前后血清hs-CRP和尿酸水平均显著高于对照组(P<0.01);不同心功能分级间hs-CRP和尿酸水平比较,均有极显著性差异(心功能Ⅳ级>Ⅲ级>Ⅱ级,P<0.01);心功能3个级别的患者在治疗后血清hs-CRP和尿酸水平均较治疗前明显降低(P<0.01)。结论 CHF患者血清hs-CRP和尿酸水平与心功能不全严重程度密切相关,动态观察两者水平的变化对判断病情、观察治疗效果及评价预后有重要的临床价值。
Objective To investigate the clinical value of serum hs-CRP and uric acid before and after treatment in patients with chronic heart failure (CHF). Methods 105 patients with CHF were divided into grade Ⅱ ~ Ⅳ according to NYHA classification. Serum hs-CRP and uric acid levels were determined before and after treatment, and were compared with 31 healthy controls (control group). Results The serum levels of hs-CRP and uric acid in CHF patients before and after treatment were significantly higher than those in the control group (P <0.01). There was significant difference in hs-CRP and uric acid levels between different cardiac function grades (Ⅳ> Ⅲ Grade> grade II, P <0.01). Serum hs-CRP and uric acid levels in 3 patients with cardiac function were significantly lower than those before treatment (P <0.01). Conclusions The serum levels of hs-CRP and uric acid in CHF patients are closely related to the severity of cardiac insufficiency. The dynamic changes in the levels of serum hs-CRP and uric acid may have important clinical value in judging the disease, observing the therapeutic effect and evaluating the prognosis.