目的　研究轻度高温、亚低温对局灶脑缺血抑制性氨基酸的影响。　方法　建立大鼠大脑中动脉缺血再灌注模型 ,诱导目标脑温 ,用 HPL C荧光法检测脑组织 GABA含量。　结果　轻度高温组GABA短暂增高后下降 ,亚低温组 GABA持续增高。　结论　轻度高温使脑内 GABA水平下调 ,在加重缺血神经元损伤方面起着不容忽视的作用 :亚低温使 GABA水平持续上调 ,在保护缺血神经元方面起重要作用。 Objective To study the effects of mild hypothermia and mild hypothermia on inhibitory amino acids in focal cerebral ischemia. Methods The rat middle cerebral artery occlusion (MCAO) model was established, and the target brain temperature was induced. The content of GABA in brain tissue was detected by HPL C fluorescence method. Results After mild hypothermia, GABA increased temporarily and then decreased. GABA in hypothermia group continued to increase. Conclusions Mild hypothermia can decrease the level of GABA in the brain and play an important role in aggravating the damage of ischemic neurons. Mild hypothermia keeps GABA level up continuously and plays an important role in protecting ischemic neurons.