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目的观察中药黄芪对缺血后脑细胞线粒体的保护作用。资料和方法利用大鼠局灶性脑缺血再灌注损伤模型，测定单纯缺血组动物脑细胞线粒体丙二醛的含量及膜流动性的变化，以及缺血即刻、缺血后６、１２、２４、４８不同时点腹腔注射黄芪各组动物上述指标的变化，对比分析用药各组与盐水对照组观察结果的差异。结果缺血侧大脑半球线粒体内丙二醛含量明显增加，膜流动性明显降低，丙二醛水平与膜微粘度关系密切。缺血后２４小时内注射黄芪均能显著降低线粒体丙二醛含量和膜微粘度，缺血后４８小时用药线粒体生化指标无显著下降，但仍有一定的保护作用。结论黄芪对脑缺血线粒体有保护作用，早期用药疗效显著。
Objective To observe the protective effect of Radix Astragali on mitochondria of ischemic brain cells. Materials and Methods The model of focal cerebral ischemia-reperfusion injury in rats was used to determine the content of mitochondrial MDA and the changes of membrane fluidity in brain cells of rats subjected to ischemia alone. The changes of mitochondrial malondialdehyde (MDA) 24,48 astragalus at different time points intraperitoneal injection of the above indicators of animals changes, comparative analysis of the treatment group and saline control group differences in the observation results. Results The contents of malondialdehyde (MDA) in mitochondria of ischemic hemisphere increased significantly, the fluidity of membrane decreased significantly, and the level of malondialdehyde was closely related to the microviscosity of membrane. Intravenous injection of Astragalus within 24 hours after ischemia can significantly reduce the content of mitochondrial malondialdehyde and membrane microviscosity. There was no significant decrease in mitochondrial biochemical parameters 48 hours after ischemia, but there was still some protective effect. Conclusion Astragalus has a protective effect on cerebral ischemia and mitochondria, and the effect of early treatment is obvious.