丙型肝炎患者的血清病毒负荷可预测抗病毒治疗的效果,但在丙型肝炎的自然病程中,血清病毒负荷的波动还不清楚。为了确定HCV感染过程中病毒负荷究竟是处于稳定状态还是动态变化之中,作者对一组(49例女性)由于应用同一批受污染的免疫球蛋白而感染HCV 1b型的人群进行了研究。所有患者在整个研究期间均未接受抗病毒治疗。病毒负荷用Roche检测仪测定。 结果:49例患者感染时的平均年龄为30.3岁(18.5～43岁),随访时间平均4.1年(1.2～5年);肝脏炎症程度为0～7(平均3,SD±1),纤维化分期为0～4(平均1,SD±1)。病毒负荷的基线水平与最后测定的病毒负荷水平分别为-0.65log_(10)病毒拷贝/mL Serum viral load in patients with hepatitis C predicts the effectiveness of antiviral therapy, but fluctuations in serum viral load remain unclear in the natural history of hepatitis C. To determine whether the viral load was stable or dynamic during HCV infection, the authors studied a population of 49 women who were HCV 1b infected with the same batch of contaminated immunoglobulins. All patients received no antiretroviral therapy throughout the study period. The virus load was measured with a Roche detector. Results: The average age of infection in 49 patients was 30.3 years (18.5-43 years), mean follow-up time was 4.1 years (1-2.5 years); liver inflammation ranged from 0-7 (mean SD 3 ± SD), fibrosis Staging is 0-4 (average 1, SD ± 1). The baseline levels of viral load and the final measured viral load levels were -0.65 log_ (10) virus copies / mL