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目的:探讨射频消融术对射血分数保留心力衰竭(HFpEF)合并持续性心房颤动(PAF)患者左心室心肌收缩功能的影响。方法:前瞻性纳入2019年5月至12月在南京医科大学第一附属医院心血管内科首次接受射频消融术的HFpEF-PAF患者，分别于术前，术后5 d、1个月、3个月、6个月及12个月采集心电图和经胸超声心动图资料，通过复查心电图是否为心房颤动(房颤)或心房扑动，将患者分为房颤复发组与未复发组，获取左心室压力-应变环，比较两组患者消融术前以及房颤未复发组消融术后各个随访时间点的左心室应变及做功参数。结果:研究共纳入30例HFpEF-PAF患者，其中4例术后3个月复查心电图提示房颤复发[复发组，年龄(63.25±6.40)岁，男2例]；7例因新型冠状病毒肺炎疫情无法完成随访；房颤未复发且完成1年随访的患者19例[未复发组，年龄(61.88±8.50)岁，男8例]。与未复发组相比，复发组术前的整体纵向应变(GLS)较低(2.41±0.64对8.00±2.83，n P＝0.028)。与消融术前相比，未复发组在术后随访各个时间点GLS、整体做功效率、有用功及做功指数均明显改善。n 结论:经射频消融术恢复并维持窦性心律后，HFpEF-PAF患者左心室收缩功能明显改善，压力应变环作为心肌做功评估的新方法，可用于定量分析患者左心室收缩功能。“,”Objective:To evaluate the effect of catheter ablation on myocardial work and left ventricular systolic function in patients with heart failure with preserved ejection fraction (HFpEF) and persistent atrial fibrillation(PAF).Methods:Thirty consecutive patients with HFpEF and PAF who underwent the first catheter ablation were prospectively enrolled in the Department of Cardiology of the First Affiliated Hospital with Nanjing Medical University from May to December 2019.Transthoracic echocardiography and electrocardiogram(ECG) data were performed collected before ablation, and within 5 days, 1st, 3rd, 6th and 12th month after ablation, respectively.Patients were divided into atrial fibrillation (AF) reccurence group and non-reccurence group according to postablation ECG.Left ventricular global longitudinal strain (GLS) and myocardial work parameters were acquired before and at each time point of follow-up after ablation.Baseline datas were compared between two groups.And the data of each time point in non-reccurence group were analysed.Results:In this study, AF recurrence occurred in 4 patients [mean age (63.25±6.40) years old , 50% male] at the 3rd month after ablation, and 7 patients failed to follow up due to the COVID-19 epidemic.Finally, 19 patients in non-reccurence group completed one year follow-up [mean age (61.88±8.50) years old , 42% male]. Patients with AF recurrence had lower absolute value of GLS at the baseline [non-recurrence group vs.recurrence group, (12.41±0.64) vs.(8.00±2.83),n P=0.028]. Compared with pre-ablation, GLS, work efficiency, wasted work and myocardial work index increased significantly at all stages of follow-up (n P<0.05).n Conclusion:The left ventricular structure and systolic function of the patients with HFpEF and PAF can be significantly improved after recovery and maintenance of sinus rhythm by catheter ablation.The estimation of myocardial work by PSL, as a novel method, can quantitatively analyze left ventricular systolic function of patients with HFpEF and PAF.