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虽然间质性肺疾病(ILD)代表1组1百多种独特的疾病,但其发病机理都有某些共同的基本特征,特别是其中许多疾病,具有局限于下呼吸道的免疫和炎性反应异常,从而继发性损害肺实质。因此,努力了解存在于多种疾病中的免疫和炎性细胞类型,并力图解释细胞异常和活化机理。本文综述应用单克隆抗体研究间质性肺疾病的3种用途:通过测定细胞表面表型,确定细胞群的特征;以细胞功能区分特异细胞群;单克隆抗体用作治疗剂。
Although interstitial lung disease (ILD) represents a group of more than one hundred unique diseases, its pathogenesis has some basic features in common, especially in many of these diseases, with an immune and inflammatory response confined to the lower respiratory tract Abnormal, thus secondary damage to the lung parenchyma. Therefore, efforts are made to understand the types of immune and inflammatory cells that exist in various diseases and to try to explain the mechanisms of cell abnormality and activation. This article reviews three uses of monoclonal antibodies to study interstitial lung disease: characterizing cell populations by measuring cell surface phenotypes; differentiating specific cell populations by cell function; and using monoclonal antibodies as therapeutic agents.