前文证明吡喹酬致心律失常作用存在光学异构体的特异性。本文比较了吡喹酮及其异构体对离体大鼠心房生理特性的影响,发现吡喹酮及其异构体的正性肌力作用以(+)-和(±)-吡喹酮较强,两者的EDmin、均为1×10~(-6)M,而(-)-吡喹酮最弱,EDmin为1×10~(-5)M;(+)-和(±)-吡喹酮收缩幅度平均净增率分别达84.62±14.75％和78.59±4.43％, The preceding article proves that pyrazole compensation caused by arrhythmia specificity of optical isomers. In this paper, we compared the effects of praziquantel and its isomers on the atrial physiological properties of isolated rat hearts and found that the positive inotropic effects of praziquantel and its isomers are (+) - and (±) -praziquantel (-) - praziquantel is the weakest, EDmin is 1 × 10 -5 M; (+) - and (±) ) - praziquantel contraction rate of the average net increase of 84.62 ± 14.75% and 78.59 ± 4.43%, respectively,