论文部分内容阅读
本文研究氟脲嘧啶(5—Fluorouracil,5—Fu)并用别嘌呤醇(Allopurinol,HPP)的抗肿瘤作用。5—Fu 并用 HPP 后,使5—Fu 对小白鼠的 LD_(50)数倍增大,对小白鼠艾氏腹水癌(EAC)和肉瘤_(180)(S_(180))实体型的治疗效果有明显的提高。对狗和大白鼠的亚急性毒性实验表明,5—Fu 并用 HPP 后毒性有所降低。
This article studies the antitumor effect of 5-Fu with allopurinol (HPP). 5-Fu combined with HPP increased the LD_ (50) of mice by 5-Fu several-fold and achieved the therapeutic effect on Ehrlich ascites carcinoma (EAC) and sarcoma (180) (S_ (180) Significantly improved. Subacute toxicity tests on dogs and rats showed that 5-Fu and HPP toxicity was reduced.