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目的探讨青年人血清血管紧张素Ⅱ与冠心病的关系。方法选择146例年龄≤45岁疑诊冠心病并行冠脉造影检查的患者,分为冠心病组86例和对照组60例。冠心病组又分单支病变亚组(45例)、双支病变亚组(15例)和三支病变亚组(26例),分析血清血管紧张素Ⅱ与冠状动脉病变严重程度的关系。结果冠心病组血清血管紧张素Ⅱ水平显著高于对照组(P<0.05);随着冠状动脉病变血管支数的增加,血清AngⅡ水平逐渐增加。经Cumula-tive Logit模型分析,在调整了其他多因素后,血清AngⅡ水平与冠状动脉病变支数独立相关(OR=1.006,95%置信区(1.0011,.021),P<0.01)。结论在青年人群中,血管紧张素Ⅱ与冠心病密切相关,是其独立危险因素之一。
Objective To investigate the relationship between serum angiotensin Ⅱ and coronary heart disease in young people. Methods A total of 146 patients aged ≤45 years with suspected coronary heart disease undergoing coronary angiography were enrolled and divided into coronary heart disease group (86 cases) and control group (60 cases). Coronary heart disease group was divided into subgroups of single disease (45 cases), double lesions group (15 cases) and three lesions group (26 cases), analysis of serum angiotensin Ⅱ and the severity of coronary artery disease. Results The level of serum angiotensin Ⅱ in coronary heart disease group was significantly higher than that in control group (P <0.05). The level of serum angiotensin Ⅱ was gradually increased with the increase of vascular lesion in coronary artery. After adjusting for other factors, the level of serum AngⅡ was independently associated with the number of coronary lesions (OR = 1.006, 95% confidence interval (1.0011, .021), P <0.01) by Cumula-tive Logit model. Conclusion Among young people, angiotensin Ⅱ is closely related to coronary heart disease, which is one of the independent risk factors.