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目的观察CCAAT/增强子结合蛋白-α(C/EBPα)在结肠癌组织中的表达量变化及其临床意义。方法用Western blot法分别对41例结肠癌患者的癌组织和对应的癌旁正常组织中的C/EBPα的表达情况进行检测,并对C/EBPα的表达和结肠癌的临床病理参数、预后生存率之间的关系进行统计分析。结果 41例正常癌旁组织中,C/EBPα出现低表达2例,高表达39例,低表达率为4.88%;41例结肠癌组织中,C/EBPα出现低表达32例,高表达9例,低表达率为78.05%。结肠癌组织中C/EBPα的低表达率与正常癌旁组织相比,差异有统计学意义(P<0.05)。41例结肠癌组织中,C/EBPα的表达与结肠癌患者的性别、年龄、肿瘤大小及结肠癌的组织学分类等临床病理参数无关(P>0.05),但和结肠癌的原发灶-淋巴结-远处转移(TNM)分期有着密切的关系(P<0.05)。低表达组和高表达组患者的中位生存时间分别为31.5,54.2个月,差异有统计学意义(P<0.05)。结论 C/EBPα在结肠癌中低表达,与结肠癌的TMN分期和预后生存率有着密切关系,对今后结肠癌的早期诊断和靶向治疗有着重要意义。
Objective To observe the changes of CCAAT / enhancer binding protein-α (C / EBPα) expression in colon cancer tissues and their clinical significance. Methods Western blot was used to detect the expression of C / EBPα in 41 cases of colon cancer and its corresponding normal tissues. The expressions of C / EBPα and clinicopathological parameters of colon cancer, prognosis The relationship between the rate of statistical analysis. Results Among the 41 cases of paracancerous tissues, there were 2 cases with low expression of C / EBPα, 39 cases with high expression and 4.88% low expression. In 41 cases of colon cancer, there were 32 cases with low expression of C / EBPα and 9 cases with high expression , Low expression rate of 78.05%. The low expression rate of C / EBPα in colon cancer tissues was significantly different from that in normal tissues (P <0.05). In 41 colon cancer tissues, the expression of C / EBPα was not correlated with clinicopathological parameters (P> 0.05), such as gender, age, tumor size, histological classification of colon cancer, Lymph node - distant metastasis (TNM) stage is closely related (P <0.05). The median survival time was 31.5 and 54.2 months respectively in low-expression group and high-expression group, the difference was statistically significant (P <0.05). Conclusion The low expression of C / EBPα in colon cancer is closely related to the TMN stage and prognosis of colon cancer, which is of great significance for the early diagnosis and targeted therapy of colon cancer in the future.