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子痫前期是妊娠期特有的疾病。目前子痫前期的病因和发病机制尚未完全阐明,在其发生和发展过程中涉及到多种因素,其中肾素-血管紧张素系统(RAS)失调是子痫前期重要发病原因之一,参与子痫前期的病理生理学变化。本文就系统循环和子宫胎盘RAS各组分,尤其胃促胰酶(Chymase)和AT1受体自身抗体(AT1-AA),在子痫前期的发生和发展中的变化和作用进行阐述。
Preeclampsia is a unique disease during pregnancy. At present, the etiology and pathogenesis of preeclampsia have not yet been fully elucidated. There are many factors involved in the pathogenesis and development of preeclampsia. One of the most important causes of preeclampsia is disorder of renin-angiotensin system (RAS) Pathophysiology of preeclampsia. This article describes the changes and roles of systemic circulation and various components of the uterine placenta RAS, especially Chymase and AT1 receptor autoantibodies (AT1-AA), in the development and progression of preeclampsia.