实体瘤内微环境常为酸性ｐＨ。近年的研究证实 ,酸性的细胞外ｐＨ(ｐＨｅ)抑制了非ＭＨＣ限制性免疫活性效应细胞的细胞毒作用 ,是降低过继转输肿瘤杀伤细胞治疗肿瘤疗效的重要原因之一。该文作者认为 ,在肿瘤内 ,细胞毒细胞的活化可能在此前已被低ｐＨｅ削弱。因而 ,该作者研 Solid tumor microenvironment often acidic pH. Recent studies have confirmed that acidic extracellular pH (pHe) inhibits the cytotoxic effect of non-MHC-restricted immunocompetent effector cells is one of the important reasons to reduce the success of adoptive transfer of tumor killer cells in the treatment of tumors. The authors believe that activation of cytotoxic cells may have been previously impaired by low pHe in tumors. Therefore, the author research