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通过苯环上有取代基的α,β-二溴苯丙酰氯与适量另丁胺或异丙胺反应,得近于等量的α-溴代桂皮酰胺顺、反异构体。用此法并经薄层层析分离得间氯-α-溴代桂皮酰另丁胺等10对顺、反几何异构体,其中以对溴-和对氯-顺式-α-溴代桂皮酰另丁胺的抗惊作用(MES)较强。药理实验表明,这些异构体的构型、苯环及酰胺氮上的取代基对其生物活性都有一定影响。
The α, β-dibromobenzene propionyl chloride with substituents on the benzene ring is reacted with an appropriate amount of butylamine or isopropylamine to give approximately equal amounts of cis and trans isomers of α-bromocinnamide. By this method and by thin layer chromatography isolated chloro-α-bromo cinnamoyl butylamine and other 10 pairs of cis and trans geometric isomers, which p-bromo and p-chloro-cis-α-bromo Cinnamoyl other butylamine anti-shock (MES) stronger. Pharmacological experiments show that the configuration of these isomers, benzene ring and amide nitrogen substituents on their biological activity have a certain impact.