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目的通过检测胃癌组织中p21和CD44的表达情况,探讨其在胃癌发生、发展中的相关性及临床意义。方法采用免疫组化方法检测p21和CD44蛋白,在72例研究对象中的表达情况,并且应用SPSS18.0软件进行分析结果。结果男性胃癌组织中p21蛋白表达阳性率(55.0%)明显高于女性胃癌组织(31.3%)。CD44蛋白表达与胃癌患者的性别和癌组织的分化程度、淋巴结转移有关(P<0.01)。p21蛋白表达与CD44的表达呈明显负相关(P<0.05)。结论在正常胃黏膜、胃癌组织中,检测到p21蛋白表达依次减少,而CD44蛋白表达增高,提示p21蛋白和CD44蛋白的表达与胃癌的发生发展有关。
Objective To detect the expression of p21 and CD44 in gastric cancer and to explore their correlation and clinical significance in the occurrence and development of gastric cancer. Methods Immunohistochemistry was used to detect the expression of p21 and CD44 proteins in 72 subjects and the results were analyzed by SPSS18.0 software. Results The positive rate of p21 protein (55.0%) in gastric cancer tissues was significantly higher than that in female gastric cancer tissues (31.3%). The expression of CD44 protein was correlated with the gender and the differentiation degree of gastric cancer and lymph node metastasis (P <0.01). The expression of p21 protein was negatively correlated with the expression of CD44 (P <0.05). Conclusions In normal gastric mucosa and gastric cancer tissues, the expression of p21 protein and CD44 protein were decreased, while the expression of p21 protein and CD44 protein were correlated with the occurrence and development of gastric cancer.