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目的：研究温热化疗对膀胱癌细胞超微结构的影响及预防复发的效果。方法：２０例膀胱癌患者，术中使用丝裂霉素Ｃ（ＭＭＣ）加生理盐水行膀胱灌注温热化疗，膀胱内温度维持在４３～５０℃。温热化疗前、后取肿瘤组织送光镜及电镜观察。结果：温热化疗后光镜下见肿瘤细胞凋亡。电镜下见肿瘤细胞核碎裂，胞质内细胞器空泡变性。随访６～２２个月，１８例无复发，１例术后２周死于消化道出血，１例频发性肿瘤术后３个月复发，但肿瘤数目较以前明显减少。结论：温热化疗对膀胱癌细胞有杀灭作用，联合手术治疗可有效地降低肿瘤的复发率
Objective: To study the effect of hyperthermia chemotherapy on the ultrastructure of bladder cancer cells and the effect of preventing recurrence. Methods: Twenty patients with bladder cancer underwent intravesical instillation of mitomycin C (MMC) plus normal saline intravesical instillation. The intravesical temperature was maintained at 43-50 ℃. Tumor tissue before and after the light microscopy and electron microscopy. Results: Tumor cell apoptosis was observed under light microscope after warm chemotherapy. Under the electron microscope, the tumor cell nuclear fragmentation and cytoplasmic organelle vacuolar degeneration. Follow-up ranged from 6 to 22 months. No recurrence was observed in 18 cases, 1 case died of gastrointestinal bleeding 2 weeks after operation, and 1 case recurred after 3 months of operation. However, the number of tumors was significantly reduced than before. Conclusion: Warm chemotherapy has a killing effect on bladder cancer cells, combined with surgical treatment can effectively reduce the recurrence rate of the tumor