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目的 观察羟基喜树碱 (HCPT)对晚期胃肠道恶性肿瘤治疗效果。方法 治疗组 56例晚期消化道肿瘤患者 ,应用含 HCPT化疗方案治疗 ,对照组 36例晚期消化道肿瘤患者 ,应用不含HCPT化疗方案治疗。结果 治疗组 56例可以评价疗效的患者中 ,CR6例 ,PR19例 ,NC2 1例 ,PD10例 ,总有效率 4 4 .6 4 % ,其中大肠癌的有效率 4 8% (12 / 2 5)。对照组总有效率 36 .11% ,经统计学处理 ,P<0 .0 5,两组有显著性差异。结论 HCPT对晚期胃肠道恶性肿瘤有良好的治疗效果
Objective To observe the effect of hydroxycamptothecin (HCPT) on the treatment of advanced gastrointestinal cancer. Methods 56 patients with advanced gastrointestinal cancer patients treated with HCPT chemotherapy, 36 patients with advanced gastrointestinal cancer control group, the application of non-HCPT chemotherapy regimen. Results Among the 56 patients who could evaluate the curative effect, CR6, PR19, NC2 and PD10 had a total effective rate of 44.46%, and the effective rate of colorectal cancer was 48% (12/2 5) . The control group, the total effective rate 36.11%, by statistical analysis, P <0. 05, the two groups were significantly different. Conclusion HCPT has a good therapeutic effect on advanced gastrointestinal cancer