【摘 要】
：
To date, little information has been available regarding genes involved in the regulation of embryonic cell development, which participate in retinoic acid-indu
【机 构】
：
Department of Neurosurgery, Deyang People’s Hospital, Deyang 618000, Sichuan Province, China“,”Depar
论文部分内容阅读
To date, little information has been available regarding genes involved in the regulation of embryonic cell development, which participate in retinoic acid-induced neural tube defects in mice.Previous studies have revealed seven differentially expressed genes involved in neural tube developmental defects. However, gene expression and regulation is a complex process. Therefore,gene expression differences between normal and defective neural tubes at 9.5 and 10.5 days were compared. A total of eight differentially expressed genes exhibited coincident alterations at embryonic 9.5 and 10.5 days. In mice with retinoic acid-induced neural tube defects, NeK7, IGFBP5,ZW10, Csf3r, PSMC6, Cdk5, and Rb1 expressions were downregulated, but Apoa-4 expression was upregulated. These results were confirmed by North blot hybridization. Results suggested that NeK7, IGFBP5, ZW10, Csf3r, PSMC6, Cdk5, Rb1, and Apoa-4 are important regulatory factors involved in neural tube defects.
其他文献
目的总结利普刀(LEEP刀)治疗宫颈癌前病变的临床疗效。方法 63例宫颈癌前病变患者,均接受LEEP刀治疗,评价其临床治疗效果。结果 63例患者中一次性完全切除59例(93.65%),手术
A bioactive compound from Paecilomyces tenuipes(BCPT)has an inhibitory effect on monoamine oxidase A(MAO-A)in vitro.Researchers have thought that BCPT may be a
Previous studies using magnetic resonance imaging(MRI)and functional MRI to study depression have primarily focused on proton magnetic resonance spectroscopy(1H
目的 探究分析性激素6项在不孕症诊断治疗中的临床应用.方法 选取200例不孕症女性患者设为观察组,同期100例体检健康女性志愿者作为对照组,两组研究对象均进行性激素6项指标
The phosphatidylinositol-3 kinase (PI3K)/Akt pathway and brain-derived neurotrophic factor (BDNF) are involved in neurological functional recovery following cer
In vitro studies have demonstrated that many factors of bone morphogenetic proteins (BMPs) induce cholinergic differentiation of neural stem cells. However, BMP
目的探讨异位妊娠患者采取腹腔镜手术治疗的临床效果。方法选取行腹腔镜手术治疗的46例异位妊娠患者作为观察组,另选取同期接受开腹手术治疗的30例异位妊娠患者作为对照组。
Clinical and animal experiments have proved that intrathecal injection of butorphanol has an analgesic effect. However, whether the analgesic effect is associat
Numerous studies have confirmed that vascular endothelial growth factor (VEGF) improves the function of neural cells following spinal cord injury (SCI). However