论文部分内容阅读
目的:比较胰岛素泵持续皮下胰岛素输注(CSII)与多次皮下胰岛素注射(MDII)治疗儿童1型糖尿病(T1DM)的疗效。方法:采用PubMed、CNKI等进行检索,检索词包括“胰岛素泵持续皮下胰岛素输注”、“多次皮下胰岛素”、“1型糖尿病”、“儿童”;continuous subcutaneous insulin infu-sion by insulin pump,multiple daily insulin injection,搜索CSII组为CSII,MDII组为MDII的随机对照实验。结果:共纳入符合条件文献11篇,共有289例T1DM患儿,其中CSII组143例,MDII组146例。CSII与MDII治疗儿童T1DM所用胰岛素用量的各研究具有较好的异质性(χ2=0.66,P=0.88>0.05),可利用固定效应模型进行分析。CSII与MDII治疗儿童T1DM糖化血红蛋白(HbA1c)、低血糖发生次数的各研究均具有显著的异质性(χ2=13.77,13.93,P均<0.05),利用随机效应模型进行分析。结果显示CSII组的HbA1c、所用胰岛素用量、低血糖发生次数均明显低于MDII组。结论:CSII是一种比较有效治疗儿童糖尿病的方法。
Objective: To compare the efficacy of insulin pump continuous subcutaneous insulin infusion (CSII) and multiple subcutaneous insulin injections (MDII) in the treatment of childhood type 1 diabetes (T1DM). Methods: PubMed and CNKI were used to search. The search terms included “continuous subcutaneous insulin infusion of insulin pump”, “multiple subcutaneous insulin”, “type 1 diabetes”, “child” insulin infu-sion by insulin pump, multiple daily insulin injection, search CSII CSII, MDII MDII randomized controlled trial. Results: A total of 11 eligible patients were enrolled in this study. A total of 289 T1DM children were enrolled, including 143 in the CSII group and 146 in the MDII group. The studies of insulin dosage for CSDM and MDII in children with T1DM showed good heterogeneity (χ2 = 0.66, P = 0.88> 0.05), which could be analyzed by the fixed effect model. CSII and MDII treatment of children with T1DM glycated hemoglobin (HbA1c), the incidence of hypoglycemia in each of the studies have significant heterogeneity (χ2 = 13.77,13.93, P <0.05), the use of random effects model for analysis. The results showed that CSII group HbA1c, the amount of insulin used, the frequency of hypoglycemia were significantly lower than the MDII group. Conclusion: CSII is a more effective treatment of children with diabetes.