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目的探讨男性不育与染色体核型异常的关系。方法按照精液常规检查结果,将369例男性不育症患者分为4组(无精子症组61例,少精子症组98例,弱精子症组117例,精液正常组93例),采用常规外周血淋巴细胞染色体制备方法对上述患者进行细胞遗传学检测。结果染色体异常检出率为8.4%(31/369),其中无精子症组19.7%(12/61),少精子症组7.1%(7/98),弱精子症组6.0%(7/117),精液正常组5.4%(5/93)。结论染色体异常是男性不育的主要遗传因素。
Objective To investigate the relationship between male infertility and chromosomal abnormalities. Methods According to the results of routine semen examination, 369 male infertility patients were divided into 4 groups (61 cases of azoospermia group, 98 cases of oligozoospermia group, 117 cases of asthenospermia group and 93 cases of normal semen group) Peripheral blood lymphocyte chromosome preparation methods for these patients for cytogenetic detection. Results The detection rate of chromosomal abnormalities was 8.4% (31/369), including 19.7% (12/61) in azoospermia group, 7.1% (7/98) in oligospermia group and 6.0% in asthenospermia group (7/117 ), Normal semen 5.4% (5/93). Conclusion Chromosomal abnormalities are the main genetic factors of male infertility.