为阐明体内脂质氧化修饰的可能机制,作者将磷脂直接与糖反应后生成预先糖基化终产物(AGEs),再观察AGEs进一步引起脂质氧化的可能性。体外实验时磷脂与糖反应很易形成磷脂连结的AGEs,与蛋白质预先糖基化所形成的AGEs在光吸收、荧光和免疫化学性质方面相似。不饱和脂肪酸的氧化速率(由活性醛形成的多少来衡量),与脂质预 In order to elucidate the possible mechanisms of lipid oxidation in vivo, the authors reacted phospholipids directly to sugars to generate pre-glycosylation end products (AGEs), and further examined the potential for AGEs to further cause lipid oxidation. In vitro phospholipid reaction with sugar is very easy to form phospholipid-linked AGEs, which are similar in terms of light absorption, fluorescence and immunochemical properties to AGEs formed by pre-glycosylation of proteins. The rate of oxidation of unsaturated fatty acids (as measured by how much active aldehyde is formed)