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1965年,Liebow 等提出“脱屑性间质性肺炎(DIP)”这一新的疾病。本病的特点为:肺泡囊中有大量胞浆内空泡变性的细胞聚集与肺泡表面Ⅱ型肺细胞的数量增加。由于本病的良性过程及其对类固醇的良好反应,现已从间质性肺炎中独立出来。DIP 的病原学与发病机制尚不清楚。本文旨在明确聚集在肺泡腔中细胞的本质,并提供这些细胞在本病发病机制中的可能作用。作者介绍了4例 DIP 患者(病例从略)。全部患者均进行了肺活检,并用光学显微镜,免疫荧光和电子显微镜进行了观察。本病急性期肺活检标本显示两个特点:(1)肺泡表面的Ⅱ型细胞数量增加;(2)在肺泡腔中大量聚集特征性的胞浆内空泡变性的大单核细胞。DIP 患者的胞内仅见到少量的淋巴
In 1965, Liebow et al. Proposed a new disease called “desquamative interstitial pneumonia (DIP).” The disease is characterized by: a large number of alveolar vesicle degeneration within the cytoplasm of cells aggregated and the number of alveolar surface type II cells increased. Due to the benign process of the disease and its good response to steroids, it is now independent of interstitial pneumonia. The etiology and pathogenesis of DIP is not clear. This article aims to clarify the nature of the cells that accumulate in the alveolar space and provide a possible role for these cells in the pathogenesis of this disease. The authors describe 4 cases of DIP patients (cases omitted). All patients underwent lung biopsy and observed by light microscopy, immunofluorescence and electron microscopy. The acute lung biopsy specimens show two characteristics: (1) the number of type II cells on the alveolar surface increased; (2) the accumulation of large numbers of characteristic cytoplasmic vacuolar degeneration of large mononuclear cells in the alveolar space. DIP patients only see a small amount of intracellular lymph