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目的 探讨 CD44 v6和 nm2 3在直肠癌中表达及其意义。方法 应用免疫组化方法检测 5 4例直肠癌中CD44 v6和 nm2 3蛋白表达。结果 CD44 v6表达与直肠癌的分化程度、浸润深度无显著相关 (P>0 .0 5 ) ,与有无淋巴结转移密切相关 (P<0 .0 5 )。 nm2 3与直肠癌浸润深度无显著相关 (P>0 .0 5 ) ,与分化程度、有无淋巴结转移密切相关(P<0 .0 5 )。直肠癌中 CD44 v6和 nm2 3表达呈负相关 ,CD44 v6阳性伴 nm2 3阴性表达的患者发生淋巴结转移的可能性大。结论 CD44 v6和 nm2 3在直肠癌中的表达与肿瘤的浸润转移密切相关 ,两者在直肠癌淋巴结转移中起拮抗作用 ,可作为临床预测浸润转移的一个重要参考指标。
Objective To investigate the expression of CD44 v6 and nm23 in rectal cancer and its significance. Methods Immunohistochemistry was used to detect the expression of CD44 v6 and nm23 protein in 54 cases of rectal cancer. Results There was no significant correlation between the expression of CD44v6 and the degree of differentiation and depth of invasion in rectal cancer (P> 0.05). There was a close correlation between CD44v6 expression and lymph node metastasis (P <0.05). There was no significant correlation between the expression of nm23 and the depth of invasion of rectal cancer (P> 0.05), and the degree of differentiation and lymph node metastasis (P <0.05). There was a negative correlation between the expression of CD44 v6 and nm23 in rectal cancer and the possibility of lymph node metastasis in patients with CD44 v6 positive and nm23 negative expression. Conclusion The expression of CD44 v6 and nm23 in rectal cancer is closely related to the invasion and metastasis of tumor. Both of them play an antagonistic role in lymph node metastasis of rectal cancer and may serve as an important reference index for clinical prediction of invasion and metastasis.