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目的探讨运动对睡眠呼吸暂停模型SD大鼠肾素血管紧张素系统及血压的影响。方法选取SD雄性3月龄大鼠32只,按随机数字表法分为4组,分别为睡眠呼吸暂停组、运动睡眠呼吸暂停组、运动对照组及空白对照组,每组8只。采用间歇性缺氧、多平台水环境睡眠剥夺法构建睡眠呼吸暂停动物模型,采用中等强度跑台运动进行干预,实验时间8周。实验终点测量大鼠有创动脉压,取血测定血浆肾素、血管紧张素Ⅱ、醛固酮水平。结果各组间有创动脉压比较差异有统计学意义(P<0.05),两两比较显示睡眠呼吸暂停组有创动脉压高于其余3组,差异均有统计学意义(P<0.05),运动睡眠呼吸暂停组有创动脉压低于睡眠呼吸暂停组(P<0.05),高于运动组和空白对照组(P<0.05),运动组和空白对照组2组间差异无统计学意义(P>0.05);各组间血浆肾素水平差异有统计学意义(P<0.05),两两比较显示睡眠呼吸暂停组高于其余3组,差异均有统计学意义(P<0.05),运动睡眠呼吸暂停组血浆肾素水平低于睡眠呼吸暂停组(P<0.05),高于运动对照组(P<0.05),也高于空白对照组(P<0.05),而运动对照组和空白对照组差异无统计学意义(P>0.05);各组间血管紧张素Ⅱ差异有统计学意义(P<0.05),两两比较显示睡眠呼吸暂停组显著高于其余3组,差异均有统计学意义(P<0.01),运动睡眠呼吸暂停组血管紧张素Ⅱ水平低于睡眠呼吸暂停组(P<0.05),高于其余2组,两两比较显示和运动对照组差异有统计学意义(P<0.05),其他组间比较差异均无统计学意义(P>0.05);各组间醛固酮水平比较差异有统计学意义(P<0.05),两两比较显示睡眠呼吸暂停组高于其余3组,差异均有统计学意义(P<0.05),其他组间比较差异均无统计学意义(P>0.05)。结论运动能抑制睡眠呼吸暂停综合征模型大鼠的血压升高,抑制肾素血管紧张素系统。
Objective To investigate the effect of exercise on renin-angiotensin system and blood pressure in SD rats with sleep apnea syndrome. Methods Thirty-two SD male 3-month-old rats were randomly divided into 4 groups according to random number table: sleep apnea group, exercise sleep apnea group, exercise control group and blank control group, with 8 rats in each group. The animal model of sleep apnea was established by intermittent hypoxia and multi-platform water environment sleep deprivation method. The moderate-intensity treadmill exercise was used to intervene for 8 weeks. The mean arterial blood pressure was measured at the end of the experiment. Plasma renin, angiotensin Ⅱ and aldosterone levels were measured. Results There was a significant difference in arterial pressure between groups (P <0.05). Comparing the two groups showed that arterial pressure in sleep apnea group was higher than the other three groups (P <0.05) Compared with exercise group and blank control group (P <0.05), there was no significant difference between exercise group and blank control group (P <0.05), while there was no significant difference between exercise and sleep apnea group > 0.05). There was a significant difference in plasma renin levels between groups (P <0.05), and any pairwise comparison showed that sleep apnea group was higher than the other three groups (P <0.05) The plasma renin level in apnea group was lower than that in sleep apnea group (P <0.05), higher than that in exercise control group (P <0.05), and also higher than that in blank control group (P <0.05) There was no significant difference between the two groups (P> 0.05). There was significant difference between the two groups in angiotensin Ⅱ (P <0.05), and any pairwise comparison showed that the sleep apnea group was significantly higher than the other three groups, the difference was statistically significant (P <0.01). The level of angiotensin Ⅱ in exercise-induced sleep apnea group was lower than that in sleep apnea group (P <0.05), higher than the other two groups (P <0.05). There was no significant difference between the other groups (P> 0.05). The level of aldosterone in each group was significantly different (P <0.05), and the difference between the two groups was statistically significant There was no significant difference between the other groups (P> 0.05). Conclusion Exercise can inhibit the elevation of blood pressure and inhibit the renin-angiotensin system in rats with sleep apnea-syndrome.