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乳腺癌的基因治疗是近年来肿瘤治疗研究的热点,目前处于实验或临床初步应用的基因治疗方法主要有免疫基因治疗、多药耐药基因治疗、反义寡核苷酸治疗、自杀基因治疗等方法,而将基因治疗与放射性核素相结合的基因靶向近距离放射治疗的方法具有放射性核素与自杀基因对肿瘤细胞的双重杀灭作用,为肿瘤基因治疗开辟了一条崭新的途径,在这一领域进一步研究必将加快基因靶向治疗向临床应用迈进的步伐。
Gene therapy for breast cancer is a hot research topic in cancer treatment in recent years. At present, gene therapy methods that are mainly used in experiments or clinical applications include immunotherapy, multidrug resistance gene therapy, antisense oligonucleotide therapy and suicide gene therapy Method, gene therapy combined with radionuclide gene targeting brachytherapy method has the dual killing effect of radionuclide and suicide gene on tumor cells, which opens up a new way for gene therapy of tumors Further research in this area is bound to accelerate the progress of gene-targeted therapies toward clinical application.