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目的 阿莫西林（ＡＭＰＣ）与庆大霉素（ＧＭ）或奈替木星（ＮＴＬ）联合应用抗生素后效应（ＰＡＥ）的比较。方法 应用光密度法测定ＰＡＥ。结果ＡＭＰＣ单用时对金黄色葡萄球菌和粪肠球菌有较长的ＰＡＥ，对大肠埃希氏菌ＰＡＥ甚小；ＧＭ和ＮＴＬ单用对Ｇ＋球菌的ＰＡＥ亦很明显，对大肠埃希氏菌ＰＡＥ稍短，但比单用ＡＭＰＣ要长。ＮＴＬ的ＰＡＥ比ＧＭ长，可能与受试菌对ＮＴＬ敏感性高于ＧＭ有关。三种药物ＰＡＥ均有随药物浓度增加而延长的趋势。ＡＭＰＣ与４倍ＭＩＣ的ＧＭ或ＮＴＬ联用时对受试菌的ＰＡＥ均呈协同或相加效应；对Ｇ＋球菌的联合ＰＡＥ比Ｇ－杆菌明显延长；ＡＭＰＣ与 ＮＴＬ的联合ＰＡＥ长于与 ＧＭ联合的ＰＡＥ。结论 ＡＭＰＣ与 ＧＭ或ＮＴＬ联用时延长给药间隔，仍可维持强大的抗菌活性，减轻不良反应，ＡＭＰＣ与ＮＴＬ联用优于与ＧＭ联用。
Aim To compare the post antibiotic effect (PAE) of amoxicillin (AMPC) with gentamicin (GM) or netilmicin (NTL). Methods The optical density method was used to determine PAE. Results When AMPC alone was used, it had longer PAE against Staphylococcus aureus and Enterococcus faecalis and very little to Escherichia coli PAE. The PAE of GM and NTL against G + Slightly shorter, but longer than AMPC alone. The PAE of NTL was longer than that of GM, which may be related to the sensitivity of tested bacteria to NTL to be higher than GM. PAE of the three drugs tended to increase with increasing drug concentration. Combination of AMPC with GM or NTL with 4 times MIC showed a synergistic or additive effect on PAE of tested bacteria; PAE of G + cocci was significantly longer than that of G-bacteria; the combined PAE of AMPC and NTL was longer than PAE combined with GM . Conclusions When combined with GM or NTL, AMPC prolongs the administration interval and still maintains strong antibacterial activity and alleviates side effects. AMPC is better than NTL in combination with GM.