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血脑屏障SPECT 早在1960年,就进行了穿透血脑屏障的非特异性显像——用过锝酸形式的~(99m)Tc进行脑闪烁显像。另一些~(99m)Tc标记的放射性药物,象葡庚糖酸(GH)和二乙三胺五醋酸(DTPA)可改善靶/本底比值。因而,几乎十年时间内,用这些示踪剂所进行的脑闪烁显像能发现广泛的血管性和肿瘤的病理变化。然而,还不能区分灰质和白质,因为这些示踪剂只和细胞外间室有关。单光子发射计算机断层(SPECT)的出现刷新了对核医学中脑显像的技术。1980年首次有了三个SPECT和X线透射型计算机断层(CT)的比较性研究报道。Ell等人报道了209例脑的SPECT和X-CT比较:169例
Blood-brain barrier SPECT As early as 1960, non-specific imaging of the blood-brain barrier was performed - brain scintigraphic imaging was performed with ~ (99m) Tc in the form of pertechnetate. Other ~ (99m) Tc-labeled radiopharmaceuticals, such as glucoheptonic acid (GH) and diethylenetriaminepentaacetic acid (DTPA), improved target / background ratios. Thus, brain scintigraphy performed with these tracers can detect a wide range of vascular and pathological changes in tumors for almost a decade. However, it is not yet possible to distinguish between gray matter and white matter, since these tracer only relate to the extracellular compartment. The advent of single photon emission computed tomography (SPECT) has rejuvenated nuclear imaging techniques in the midbrain. For the first time in 1980 there were three comparative studies of SPECT and X-ray computed tomography (CT). Ell et al reported 209 brain SPECT and X-CT comparison: 169 cases