论文部分内容阅读
目的研究血液灌流(HP)联合血液透析(HD)对百草枯中毒严重指数(SIPP<25 mg/L的百草枯中毒患者血药浓度及预后的影响。方法符合条件的百草枯中毒患者200例入院后常规治疗,其中100例行血液灌流4 h串联血液透析2 h,采用高效液相法于此治疗前2,4,6(透析后2 h)测定百草枯浓度。结果血液灌流后2 h与灌流前相比显著下降[(6.25±1.87)mg/L降至(2.67±1.37)mg/L(P<0.01)],但延长灌流时间及串联血液透析不能连续降低百草枯浓度(P>0.05),但能降低总体病死率。结论血液灌流联合血液透析能有效清除血液中的百草枯,降低中毒严重指数较低患者的病死率。
Objective To study the effect of hemoperfusion (HP) combined with hemodialysis (HD) on the paraquat poisoning severity index (SIPP <25 mg / L paraquat poisoning patients blood concentration and prognosis.Methods Eligible paraquat poisoning patients 200 cases After routine hemodialysis 4h hemodialysis hemodialysis 2h, high-performance liquid phase method in this 2,4,6,6 (2 h after dialysis) determination of paraquat concentration.Results 2 h after hemoperfusion and (6.25 ± 1.87) mg / L to (2.67 ± 1.37) mg / L, P <0.01), but prolonged perfusion time and serial hemodialysis did not result in the continuous decrease of paraquat concentration (P> 0.05) ), But can reduce the overall mortality.Conclusion Hemoperfusion combined with hemodialysis can effectively remove paraquat in the blood and reduce the mortality of patients with severe poisoning index.