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众所周知,NK 细胞能自发的溶解肿瘤细胞,在肿瘤免疫监视中起一定作用.但内源性抑制的机理和外源性(细菌、病毒、和肿瘤等)的刺激作用,对NK 细胞活性调节的重要性尚不了解.体外试验证明,干扰素(IFN)能增加鼠和人淋巴细胞抗肿瘤和其它靶细胞的自发性细胞毒作用。脂多糖(LPS)也能增加人类淋巴细胞对肿瘤细胞的活性.作者采用Grimm和Bonavida 改良法做了体外试验,观察大肠杆菌脂多糖对NK 细胞活性的影响。取20～40岁健康者外周血的非粘附(NA)T 淋巴细胞作效应细胞,并将NA 细胞进一步分为Fcr~+与
It is well known that NK cells spontaneously lyse tumor cells and play a role in tumor immune surveillance. However, the mechanisms of endogenous inhibition and exogenous stimulation (bacteria, viruses, and tumors, etc.) modulate the activity of NK cells. The importance is not known. In vitro tests have demonstrated that interferon (IFN) can increase the spontaneous cytotoxicity of murine and human lymphocytes against tumors and other target cells. Lipopolysaccharide (LPS) can also increase the activity of human lymphocytes on tumor cells. The in vitro test was performed using the Grimm and Bonavida modified methods to observe the effect of E. coli lipopolysaccharide on the activity of NK cells. Non-adherent (NA) T lymphocytes from peripheral blood of healthy people aged 20 to 40 were used as effector cells, and NA cells were further divided into Fcr~+ and