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白藜芦醇是一种多酚类化合物,具有广泛的生理药理学作用,如抗炎症、抗氧化及抗增殖等多种生物活性,但目前其作用机制尚未完全明确。近年研究表明,白藜芦醇主要通过调控白细胞介素6/信号转导及转录活化因子3、核因子κB及分裂原活化蛋白激酶等关键信号转导通路达到其抗炎、抗氧化作用,主要通过抑制哺乳动物雷帕霉素靶蛋白信号通路作用达到其抗增殖作用。
Resveratrol is a polyphenolic compound with a wide range of physiological and pharmacological effects, such as anti-inflammatory, anti-oxidation and anti-proliferation and other biological activity, but its mechanism of action is not yet fully clear. In recent years, studies have shown that resveratrol mainly through the regulation of interleukin 6 / signal transducers and activators of transcription 3, nuclear factor kappa B and mitogen-activated protein kinases and other key signal transduction pathways to achieve its anti-inflammatory and antioxidant effects, mainly Its inhibitory effect on mammalian target of rapamycin signaling pathway to achieve its antiproliferative effect.