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1983年 Simoni 等采用绒毛直接制备染色体进行孕早期产前诊断,该法的优点:孕9～11周已能取绒毛,几天内有结果;并可于孕12周前,在门诊
In 1983, Simoni et al. Used chromosomal direct preparations of villus for prenatal diagnosis during the first trimester. The advantages of this method are: the first 9 to 11 weeks of pregnancy has been able to take the villus, the result within a few days; and 12 weeks before pregnancy in the clinic