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氢溴酸西肽普兰(citalopram hydrobromide,商品名Celexa)属于5-羟色胺选择性再摄取抑制剂,1989年以来直在欧洲使用,现已由美国FDA批准用于治疗抑郁症。 作用机理 西肽普兰是一种消旋二环氢化酞类衍生物,体外能抑制5-羟色胺的再摄取,但几乎不影响多巴胺和去甲肾上腺素的摄取。它与毒蕈碱、组胺能、肾上腺素能或血清素激活的受体仅有极小或完全没有亲和力。 药动学 西肽普兰口服后吸收迅速,约4h内可达峰值,重复用药约在1周内达到稳态水平。食物对其吸收无影响。该药主要通过肝脏的CYP3A4、2C19酶代谢,少量被
Citalopram hydrobromide (Celexa), a serotonin selective reuptake inhibitor, has been used directly in Europe since 1989 and is now approved by the U.S. FDA for the treatment of depression. Mechanism of Action Cetuximab is a racemic bicyclic hydrogenated phthalide derivative that inhibits serotonin reuptake in vitro but has little effect on dopamine and norepinephrine uptake. It has little or no affinity for muscarinic, histaminergic, adrenergic or serotonergic receptors. Pharmacokinetics Xipu Pulan rapid absorption after oral administration, up to about peak within 4h, repeat the medication within about 1 week to reach steady-state level. Food has no effect on its absorption. The drug is mainly metabolized by the CYP3A4 and 2C19 enzymes in the liver, and is found in small quantities