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在以前的报告中,我们曾研究了温里药对动物胃肠活动作用及机理~[1-3],指出温里药对胃肠平滑肌的作用是治疗“脘腹冷痛”的药理作用之一。由于中医“脘腹”不是仅指胃肠,而是整个腹部及其内脏器官;而且温里药还具有“温经散寒”祛除身体其它部位“冷痛”的作用。因此我们估计温里药可能具有广泛的镇痛作用。为了证实我们这一设想,开展了温里药镇痛作用的研究。材料附子、桂皮、小茴香、白胡椒、吴茱萸、花椒、丁香、干姜、高良姜和荜澄茄十味温里药的来源及药材鉴定同前一报告。以上十味中药均分别加蒸馏水煮沸半小时,过滤后配制成25%和100%二种浓度的煎液。为了尽可能与临床应用相一致,对水煎剂不加其它任何处理。方法和结果1.温里药对小白鼠酒石酸锑钾扭体反应次数的影响:体重18—24克的小白鼠(雌雄
In the previous report, we studied the effect and mechanism of Wenli medicine on animal gastrointestinal activity~[1-3], pointing out that the effect of Wenli medicine on gastrointestinal smooth muscle is to treat pharmacological effects of “cold abdominal pain”. one. Because Chinese medicine “stomach belly” does not refer only to the gastrointestinal tract, but to the entire abdomen and its internal organs; and it also has the effect of “warming the cold and dispelling the cold” and removing other parts of the body “cold pain”. Therefore, we estimate that Wenli medicine may have a wide range of analgesic effects. In order to confirm our idea, we carried out research on the analgesic effect of Wenli medicine. The sources of materials, including aconite, cinnamon, fennel, white pepper, wolfberry, pepper, clove, dried ginger, galangal, and cubeling, were used in the same report as the previous report. The above ten Chinese herbs were each added with distilled water and boiled for half an hour. After filtration, they were prepared into 25% and 100% decoctions. In order to be consistent with clinical application as much as possible, no other treatment is required for the decoction. Methods and Results 1. Effect of Wenli medicine on the number of writhing response of potassium citrate tartrate in mice: mice weighing 18-24 g (male and female)