论文部分内容阅读
多毛常发生在雄激素分泌过多或毛囊对雄激素刺激高敏的妇女。过去对这种疾病的治疗限于运用雌—孕激素或糖皮质激素来抑制雄激素分泌,但疗效不佳。近年来认识到:毛囊中的雄激素受体可与拮抗雄激素的药物结合,为临床治疗多毛提供了新方法。 螺旋内酯为醛固酮拮抗剂,传统用于利尿和治疗轻型高血压。现发现此药具有抗雄激素的性质。它可抑制细胞色素p—450酶,抑制雄激素的生物合成,也可通过占据靶组织的胞液和胞核受体的结合位点而抑制雄激素的作用。
Hairy follicles often occur in women with excessive androgen secretion or hair follicles that are hypersensitive to androgen. In the past the treatment of this disease was limited to the use of estrogen-progesterone or glucocorticoids to suppress androgen secretion, but the curative effect was not good. In recent years, it has been recognized that the androgen receptor in hair follicles binds to androgen-antagonizing drugs and provides a new method for the clinical treatment of hirsutism. Spironolactone is an aldosterone antagonist, traditionally used for diuretic and light-induced hypertension. It is found that the drug has anti-androgenic properties. It inhibits cytochrome p-450 enzyme, inhibits androgen biosynthesis, but also inhibits androgen effects by occupying the binding sites of cytosolic and nuclear receptors in the target tissue.