烷化剂可通过对DNA的直接攻击及使细胞处于应激状态而引起一系列反应。它可诱导许多基因表达的改变,参与细胞应激的多种功能,引起细胞对外界损伤剂的耐受,也参与癌变、突变的发生,其中诱导表达与修复相关基因可参与烷化修复的各个环节,提供细胞对烷化剂的抗性,与化学物致癌的预防相关。 Alkylating agents cause a series of reactions by direct attack on DNA and stressing the cell. It can induce a number of gene expression changes, participate in a variety of functions of cell stress, causing cells to tolerate external damage agents, also involved in carcinogenesis, mutation, in which induction of expression and repair related genes can participate in each of alkylation repair Link, provide cell resistance to alkylating agents, and prevent chemical carcinogenesis.